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Sculptra and Radiesse differ from the more well-known hyaluronic acid fillers (Restylane, Juvederm, and Voluma) in that they don’t stay in your body as a filler. They stimulate your body to make more collagen so the added volume is ultimately your own tissue. It acts slowly, so results are not appreciated for several months after beginning a Sculptra or Radiesse treatment series. The effects of these Biostimualting Fillers will eventually diminish if not maintained. It cannot be reversed the same way the other (HA) fillers can be.